Mounting evidence from clinical studies has demonstrated the association between EAT volume and increased risks for cardiovascular diseases, particularly CAD. Here, we present a comprehensive transcriptomic atlas of human pericoronary EAT, encompassing cellular states in both normal and diseased conditions. We performed snRNA-seq on pericoronary EAT samples collected from three groups of subjects: patients undergoing coronary bypass surgery for severe CAD, CAD patients with concomitant T2D, and patients with valvular diseases but without concomitant CAD and T2D as the control group.
Founded in 1956, Fuwai Hospital which belongs to the Chinese Academy of Medical Sciences (referred as “Fuwai Hospital”) is a national triple A, first-class hospital specializing in cardiovascular diseases. It is also theNational Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, and National Clinical Research Center of Cardiovascular Diseases.It is well known internationally for treatment of all kinds of complex, difficult, and severe cardiovascular diseases, and has become the world’s largest cardiovascular center, as well as a national center for clinical healthcare, medical research, disease prevention and education.
